NAC Supports Visceral Fat Metabolism and Insulin Sensitivity in Obesity

Supports respiratory function, glutathione production and detoxification.  600 mg.  

Supports cellular antioxidant defense system.  Promotes healthy lung tissue.

Made with high-quality ingredients backed by verifiable science.

N-Acetyl-l-Cysteine (NAC) is a cellular antioxidant support that specifically promotes healthy lung tissue. N-Acetyl-l-Cysteine (NAC) is a free radical scavenger that supports glutathione levels in tissues.

1 capsule, 1-3 times daily, between meals.

NAC Supports Visceral Fat Metabolism and Insulin Sensitivity in Obesity

Visceral fat, the abdominal fat that accumulates around organs, is metabolically active. In obesity, visceral fat can cause oxidative stress that can lead to DNA damage that then contributes to cell senescence and inflammation. Senescent cells are old or damaged cells that instead of dying and being cleared by the immune system stay behind and cause harm by secreting inflammatory cytokines and other nasty chemicals. One of the most frequently used biomarkers for senescent cell detection is senescence-associated β-galactosidase (SA-β-gal); p16 gene expression is another biomarker for senescence.

In this current RCT, 40 obese adults (20 in each group) waiting for bariatric surgery were assigned to either 600 mg N-acetylcysteine (NAC) or placebo daily for four weeks prior to surgery. During surgery visceral fat samples were collected and tested for p16 gene expression and SA-β-gal activity. Blood biomarkers were tested before and after the intervention, including three inflammatory markers interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor-alpha (TNF-α), as well as the glucose metabolism markers fasting glucose, insulin sensitivity (HOMA-IR), and insulin. Total cholesterol, LDL- and HDL-cholesterol, and triglycerides were also tested before and after. Anthropometric measurements of waist circumference, weight, and body mass index were assessed at the beginning and end of the study.

NAC intervention significantly decreased both SA-β-gal activity and p16 gene expression. Blood levels of IL-6, hs-CRP, fasting glucose, and insulin, along with calculations of insulin resistance were significantly reduced in the NAC group compared to placebo. No changes in lipids or anthropometric measurements were noted.

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